منابع مشابه
DNA replication checkpoint
Genomes are duplicated with a very high degree of accuracy every cell cycle. This challenging task is made more difficult by a variety of intrinsic and extrinsic agents that interrupt DNA replication. Replication forks can encounter many endogenous blocks such as transcription complexes and DNA repair machinery. External agents such as ultraviolet radiation, which produces a variety of base mod...
متن کاملDNA replication checkpoint control.
The eukaryotic cell cycle comprises two critical phases, DNA replication (S phase) and the subsequent distribution of an equivalent genome to each of two daughter cells at mitosis (M phase). A signal transduction cascade called the replication checkpoint has evolved to ensure that M phase does not occur prior to the completion of S phase. The mitotic regulators targeted by this checkpoint have ...
متن کاملRecovery from the DNA Replication Checkpoint
Checkpoint recovery is integral to a successful checkpoint response. Checkpoint pathways monitor progress during cell division so that in the event of an error, the checkpoint is activated to block the cell cycle and activate repair pathways. Intrinsic to this process is that once repair has been achieved, the checkpoint signaling pathway is inactivated and cell cycle progression resumes. We us...
متن کاملMolecular Mechanisms of DNA Replication Checkpoint Activation
The major challenge of the cell cycle is to deliver an intact, and fully duplicated, genetic material to the daughter cells. To this end, progression of DNA synthesis is monitored by a feedback mechanism known as replication checkpoint that is untimely linked to DNA replication. This signaling pathway ensures coordination of DNA synthesis with cell cycle progression. Failure to activate this ch...
متن کاملDNA Replication Checkpoint: New ATR Activator Identified
The ATR kinase is a master regulator of replication stress responses. Four new studies show that the protein ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway reacts to replication stress.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00572-3